Brefeldin A
From Wikipedia, the free encyclopedia
Brefeldin A is a lactone antibiotic produced by fungal organisms such as Eupenicillium brefeldianum. Brefeldin A interferes with protein transport from the endoplasmic reticulum to the Golgi apparatus by inhibiting transport in Golgi. In mammalian and yeast cells, the main target of brefeldin A appears to be a certain type of GTP-exchange factors responsible for activating a GTPase called Arf1p ; in turn, Arf1p is involved in the formation of transport vesicles by recruiting coat proteins to intracellular membranes. Brefeldin A was initially isolated as an anti-viral antibiotic [1] but is now primarily used in biological research to study protein transport.
[edit] Physical data
- Appearance: White to off-white crystalline powder
- Solubility: Clear colorless solution at 10mg/ml Dichloromethane.
- Clear colorless solution at 10mg/ml Methanol.
- Melting point: 297°C-205°C
[edit] External links
- Brefeldin A: insights into the control of membrane traffic and organelle structure. (Review, 1992)
- Brefeldin A: Deciphering an Enigmatic Inhibitor of Secretion. (Review, 2002)
[edit] vendors product pages
- Brefeldin A from Fermentek
- Brefeldin A from AGScientific
