Bernthsen acridine synthesis
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The Bernthsen acridine synthesis is the chemical reaction of a diarylamine heated with a carboxylic acid (or carboxylic anhydride) and zinc chloride to form a 9-substituted acridine.
Using zinc chloride, one must heat the reaction to 200-270 °C for 24hrs. The use of polyphosphoric acid will give acridine products at a lower temperature, but also with decreased yields.
[edit] References
- ↑ Bernthsen, A.; Ann. 1878, 192, 1.
- ↑ Bernthsen, A.; Ann. 1884, 224, 1.
- ↑ Popp, F. D. J. Org. Chem. 1962, 27, 2658. (DOI:10.1021/jo01054a518)
- Buu-Hoi, N. P. et al. J. Chem. Soc. 1955, 1082.
