Guaifenesin
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Guaifenesin
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| Systematic (IUPAC) name | |
| 3-(2-methoxyphenoxy)propane-1,2-diol | |
| Identifiers | |
| CAS number | 93-14-1 |
| ATC code | R05CA03 |
| PubChem | 3516 |
| DrugBank | APRD01005 |
| Chemical data | |
| Formula | C10H14O4 |
| Mol. weight | 198.216 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | 1 hour |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Oral |
Guaifenesin (gwi fen' ə sin) (INN) or guaiphenesin (former BAN) is an expectorant drug usually taken orally to assist the expectoration ("bringing up") of phlegm from the airways in acute respiratory tract infections.
Guaifenesin is also used in the experimental guaifenesin protocol in the treatment of fibromyalgia.
It was first approved by the Food and Drug Administration (FDA) in 1952.
Guaifenesin works by drawing water into the bronchi. The water both thins mucus and lubricates the airway, facilitating the removal of mucus by coughing.
It is sold under several brand names such as GuaiLife, Ethex 208, Humibid, Mucinex, and Robitussin, and it also is included in many over-the-counter cough and cold remedies.
High levels of guaifenesin can cause severe vomiting. This is common with cough syrup abusers looking to achieve a DXM high.
[edit] External links
- RxList site giving some properties
- MedlinePlus DrugInfo medmaster-a682494
- Information from MedicineNet.com
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