Pyrimethamine

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Pyrimethamine
Systematic (IUPAC) name
5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
Identifiers
CAS number	58-14-0
ATC code	P01 BD01
PubChem	4993
DrugBank	APRD00599
Chemical data
Formula	C₁₂H₁₃N₄Cl
Mol. weight	248.71 g/mol
Pharmacokinetic data
Bioavailability	well-absorbed
Protein binding	87%
Metabolism	Hepatic
Half life	96 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	B3(AU) C(US)
Legal status	℞ Prescription only
Routes	Oral

Pyrimethamine (Daraprim®) is a medication used for protozoal infections. It is commonly used as an antimalarial drug (for both treatment and prevention), and is also used in the treatment of Toxoplasma gondii infections in immunocompromised patients, such as HIV-positive individuals.

1 Mechanism of action
2 Mechanism of resistance
3 Clinical use
4 Side effects
5 Contraindications
6 References
7 External links

[edit] Mechanism of action

Pyrimethamine interferes with folic acid synthesis by inhibiting the enzyme dihydrofolate reductase. Folic acid is needed for DNA and RNA synthesis in many species, including protozoa.

[edit] Mechanism of resistance

Resistance to pyrimethamine is widespread. Mutations in the gene for dihydrofolate reductase may reduce the effectiveness of pyrimethamine (PMID 15155209). These mutations decrease the binding affinity between pyrimethamine and dihydrofolate reductase by steric interactions (PMID 14711307).

[edit] Clinical use

Pyrimethamine is typically given with a sulfonamide and folinic acid:

Sulfonamides inhibit dihydropteroate synthetase, an enzyme that participates in folic acid synthesis from para-aminobenzoic acid. Hence, sulfonamides work synergistically with pyrimethamine by blocking a different enzyme needed for folic acid synthesis.
Folinic acid (Leucovorin) is a compound that can be converted into folic acid by the human body without relying on dihydrofolate reductase. By doing so, folinic acid reduces side effects related to folate deficiency.