Thymidine
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Thymidine (more precisely called deoxythymidine can also be labelled deoxyribosylthymine, and thymine deoxyriboside) is a chemical compound, more precisely a pyrimidine deoxynucleoside. Deoxythymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA.
[edit] Structure and properties
In its composition, deoxythymidine is deoxyribose (a pentose sugar) joined to the pyrimidine base thymine.
Deoxythymidine can be phosphorylated with one, two or three phosphoric acid groups, creating respectively dTMP, dTDP or dTTP ((deoxy)thymidine mono- di- or triphosphate).
It exists in solid form as small white crystals or white crystalline powder, has a molecular weight of 242.229 u, and has a melting point of 185 °C. The stability of deoxythymidine under standard temperature and pressure (STP) is very high.
Deoxythymidine is non-toxic and as part of one of the four nucleotides in DNA it is a naturally occurring compound that exists in all living organisms and DNA viruses. RNA has uridine (uracil joined to ribose) instead. Uracil is chemically very similar to thymine, the latter being 5-methyluracil. Since thymine nucleotides are precursors of DNA, not RNA, the prefix "deoxy" is often left out, i.e., deoxythymidine is often just called thymidine.
[edit] Modified Analogs of Thymidine
Azidothymidine (AZT) - the treatment against HIV, which blocks the process of reverse transcription from the virus's RNA into DNA to be incorporated into the host cell.
Tritiated thymidine is commonly used to measure the amount of cell division in the laboratory.
[edit] External links
| Nucleic acids and oligonucleotides edit | ||
|---|---|---|
| Nucleobases: | Adenine | Thymine | Uracil | Guanine | Cytosine | Purine | Pyrimidine | |
| Nucleosides: | Adenosine | Uridine | Guanosine | Cytidine | Deoxyadenosine | Thymidine | Deoxyguanosine | Deoxycytidine | |
| Nucleotides: | AMP | UMP | GMP | CMP | ADP | UDP | GDP | CDP | ATP | UTP | GTP | CTP | cAMP | cADPR | cGMP | |
| Deoxynucleotides: | dAMP | TMP | dGMP | dCMP | dADP | TDP | dGDP | dCDP | dATP | TTP | dGTP | dCTP | |
| Ribonucleic acids: | RNA | mRNA | tRNA | rRNA | ncRNA | sgRNA | shRNA | siRNA | snRNA | miRNA | snoRNA | LNA | |
| Deoxyribonucleic acids: | DNA | mtDNA | cDNA | plasmid | Cosmid | BAC | YAC | HAC | |
| Analogues of nucleic acids: | GNA | PNA | TNA| morpholino | |
| ←Amino acids | Major families of biochemicals | Carbohydrates→ |
